BGI Genomics has extensive experience in the field of targeted metabolomics spanning accurate quantification of target metabolites, verification of hypothesis by untargeted metabolomics or other omics, and metabolic model study for specific metabolites1.

Service Description

The HM700 panel uses LC-MS/MS technology for high-throughput targeted metabolomics detection. It covers around 700 metabolites including 30 metabolite classes addressing key pathophysiological processes relevant in gut microbiota research and cancer research areas. This enables greater in-depth mining of metabolome information, while providing accurate quantification, excellent reproducibility, and high throughput. Each metabolite is quantitatively determined using the standard curve.

HM700

Project Workflow

<h4>[1]&nbsp;Liu R., et al., Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention. Nat Med, 2017. 23(7): p. 859-868.</h4>

References

How to order

HM700 high-throughput targeted metabolomics services are performed using Waters ACQUITY UPLC and SCIEX QTRAP 6500+.

<ul><li>Each metabolite has a corresponding two kinds of standard curves with broad dynamic range for absolute quantification and was corrected using isotope internal standard</li><li>3-NPH derivatization significantly achieve ultra-high sensitivity and cross-magnitude detection</li><li>Using LC-MS (SCIEX QTRAP 6500+) to increase the scope of detection</li></ul>

Sample Preparation and Services

<ul><li>Summary includes all methods and data analysis</li><li>Reports provided in Excel or PDF format</li></ul>

Quality Standard

<ul><li>Typical 5-7 weeks after sample receipt</li></ul>

Turn Around Time

Mass Spectrometry Service Specification

We accept metabolite samples in a variety of formats. Contact your BGI Genomics account representative for details for your samples.

Sample Requirements

<ul><li>LC chromatogram</li><li>Quantitative analysis</li><li>Statistical analysis&nbsp;</li><li>Function analysis</li></ul>

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HM700